This Pizza Grilled Cheese is simple sandwich with loads of flavor. This easy recipe will give you the satisfaction of pizza in a delicious panini package! You only need a few ingredients to make it and it’s so easy.

stacked grilled cheese with pepperoni baked on top and inside the sandwich.

Pepperoni Pizza Grilled Cheese is everything you love from pizza in the form of a sandwich. There’s cheese and sauce and bread and it’s toasty and has pizza flavor in every bite! You can make this recipe quick for lunch or dinner – no dough needed. Customize the grilled cheese with your favorite flavors using different kinds of bread and pizza toppings!

ingredients in pizza grilled cheese laid out on a white marble counter.

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Ingredients NEEDED

Bread: You can use any bread you like, I used classic white bread. I also enjoy using sourdough bread or ciabatta bread when making these.
Pizza sauce: Any store-bought pizza sauce will work, or you can make homemade pizza sauce or use marinara sauce.
Pepperoni Slices: Pre-cut slices of the pepperoni works fine – regular, small size, or turkey pepperoni.
Fresh Mozzarella: I recommend shredding the cheese yourself for easier melting.

Variations

Use any toppings – sausage or olives, bell peppers, onions, mushrooms, or leave it plain cheese.
Add some shredded cheddar cheese inside – our favorite pizza place adds it and it’s so good. I also love adding in some shredded parmesan cheese.
Add some spices inside with the cheese: dried oregano, Italian seasoning, garlic powder, or basil.

process shot of pizza grilled cheese being made.

How to make a Pizza Grilled Cheese

Assemble your sandwiches with sauce, shredded cheese, and pepperoni or other toppings on one side of the sandwich. Just use 1-2 tablespoons of sauce, depending on the size of your bread.
Butter one side of the bread and place in a medium skillet over medium heat. Cook until golden, then flip and cook on the other side. Add a bit of cheese and pepperoni on the top and cover to melt.

Expert tips

Don’t overfill the sandwich more than the bread can handle. Remember the sandwich is going to be squeezed between two hot plates in the press. You don’t want globs of cheese or other ingredients spilling out into the panini press, this will burn on the element of the press and create a mess.
Once you flip the grilled cheese it will melt best if you turn the stove to medium-low heat and cover the pan.
Use cooking spray instead of butter on the bread if you don’t want to use butter.

Storage

Store leftovers in the refrigerator in an airtight container. Reheat on the stove or in the air-fryer.